Chronic neuropathic pain is often severe, persistent, and poorly responsive to conventional treatments such as anti-inflammatories or opioids. Ketamine has emerged as a promising option by modulating NMDA receptors involved in pain perception and memory. Clinical studies show that ketamine can significantly reduce pain for weeks, particularly in complex neuropathic conditions. Beyond analgesia, ketamine may also improve comorbid depression and PTSD, which frequently accompany chronic pain. When combined with psychotherapy, ketamine offers an integrative approach addressing both physical suffering and psychological distress.