Chronic pain

Clínica Synaptica

Articles and therapies on chronic pain: pain that lasts longer than three to six months and affects sleep, mood and daily life. Here we gather information on chronic pain treatment and on the links between pain, the nervous system and mental health.
You will also find research on ketamine for neuropathic pain and on the role of medical cannabis in a personalised approach. Each case requires a clinical assessment and a plan that combines medical treatment with psychological support.

Cholla cactus backlit at sunset in the desert
Marta Martín Islas

Ketamine for chronic neuropathic pain

Chronic neuropathic pain is often severe, persistent, and poorly responsive to conventional treatments such as anti-inflammatories or opioids. Ketamine has emerged as a promising option by modulating NMDA receptors involved in pain perception and memory. Clinical studies show that ketamine can significantly reduce pain for weeks, particularly in complex neuropathic conditions. Beyond analgesia, ketamine may also improve comorbid depression and PTSD, which frequently accompany chronic pain. When combined with psychotherapy, ketamine offers an integrative approach addressing both physical suffering and psychological distress.

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Prickly pear cactus with spiny pads against a warm-toned wall, evoking chronic pain
Òscar Parés Franquero

Chronic pain: a debilitating affliction

Chronic pain is a complex condition lasting more than three months that affects millions of people and severely impacts quality of life. It includes multiple forms such as neuropathic, musculoskeletal, cancer-related and post-surgical pain, often without a clearly identifiable cause. Conventional treatments like anti-inflammatories and opioids show limited efficacy or significant risks. Growing evidence supports ketamine as a safe and effective option, offering sustained pain reduction and enabling multidisciplinary approaches that combine medical, psychological and rehabilitative interventions for long-term functional improvement.

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